Colaxin

Colaxin may be available in the countries listed below.

Ingredient matches for Colaxin

Cefalexin

Cefalexin is reported as an ingredient of Colaxin in the following countries:

• Myanmar

International Drug Name Search

Amopicillin

Amopicillin may be available in the countries listed below.

Ingredient matches for Amopicillin

Amoxicillin

Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Amopicillin in the following countries:

• Japan

International Drug Name Search

Teleminsoft

Teleminsoft may be available in the countries listed below.

Ingredient matches for Teleminsoft

Bisacodyl

Bisacodyl is reported as an ingredient of Teleminsoft in the following countries:

• Japan

International Drug Name Search

Piperacillin / Tazobactam Hexal

Piperacillin/Tazobactam Hexal may be available in the countries listed below.

Ingredient matches for Piperacillin/Tazobactam Hexal

Piperacillin

Piperacillin is reported as an ingredient of Piperacillin/Tazobactam Hexal in the following countries:

• Germany

Tazobactam

Tazobactam is reported as an ingredient of Piperacillin/Tazobactam Hexal in the following countries:

• Germany

International Drug Name Search

Acide citrique

Acide citrique may be available in the countries listed below.

Ingredient matches for Acide citrique

Citric Acid

Acide citrique (DCF) is known as Citric Acid in the US.

International Drug Name Search

Glossary

DCF	Dénomination Commune Française

Click for further information on drug naming conventions and International Nonproprietary Names.

Celexa

In the US, Celexa (citalopram systemic) is a member of the drug class selective serotonin reuptake inhibitors and is used to treat Anxiety and Stress, Body Dysmorphic Disorder, Depression, Generalized Anxiety Disorder, Obsessive Compulsive Disorder, Panic Disorder, Postpartum Depression, Premenstrual Dysphoric Disorder, Trichotillomania and Vulvodynia.

US matches:

• Celexa


• Celexa Solution

Ingredient matches for Celexa

Citalopram

Citalopram hydrobromide (a derivative of Citalopram) is reported as an ingredient of Celexa in the following countries:

• Canada


• United States

International Drug Name Search

Cirizine

Cirizine may be available in the countries listed below.

Ingredient matches for Cirizine

Cetirizine

Cetirizine dihydrochloride (a derivative of Cetirizine) is reported as an ingredient of Cirizine in the following countries:

• Greece

International Drug Name Search

Ridinfect

Ridinfect may be available in the countries listed below.

Ingredient matches for Ridinfect

Roxithromycin

Roxithromycin is reported as an ingredient of Ridinfect in the following countries:

• Myanmar

International Drug Name Search

Keycarbazin

Keycarbazin may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Keycarbazin

Nicarbazin

Nicarbazin is reported as an ingredient of Keycarbazin in the following countries:

• Australia

International Drug Name Search

Cefatrex

Cefatrex may be available in the countries listed below.

Ingredient matches for Cefatrex

Cefapirin

Cefapirin sodium salt (a derivative of Cefapirin) is reported as an ingredient of Cefatrex in the following countries:

• Greece

International Drug Name Search

Itagil

Itagil may be available in the countries listed below.

Ingredient matches for Itagil

Buspirone

Buspirone hydrochloride (a derivative of Buspirone) is reported as an ingredient of Itagil in the following countries:

• Portugal

International Drug Name Search

Ratidin

Ratidin may be available in the countries listed below.

Ingredient matches for Ratidin

Ranitidine

Ranitidine is reported as an ingredient of Ratidin in the following countries:

• Vietnam

International Drug Name Search

Xalotina

Xalotina may be available in the countries listed below.

Ingredient matches for Xalotina

Amoxicillin

Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Xalotina in the following countries:

• Argentina

International Drug Name Search

Cyprotérone / Ethinylestradiol Ranbaxy

Cyprotérone/Ethinylestradiol Ranbaxy may be available in the countries listed below.

Ingredient matches for Cyprotérone/Ethinylestradiol Ranbaxy

Cyproterone

Cyproterone 17α-acetate (a derivative of Cyproterone) is reported as an ingredient of Cyprotérone/Ethinylestradiol Ranbaxy in the following countries:

• France

Ethinylestradiol

Ethinylestradiol is reported as an ingredient of Cyprotérone/Ethinylestradiol Ranbaxy in the following countries:

• France

International Drug Name Search

Cedlips

Cedlips may be available in the countries listed below.

Ingredient matches for Cedlips

Oxatomide

Oxatomide is reported as an ingredient of Cedlips in the following countries:

• Japan

International Drug Name Search

Metaoxedrin SAD

Metaoxedrin SAD may be available in the countries listed below.

Ingredient matches for Metaoxedrin SAD

Phenylephrine

Phenylephrine hydrochloride (a derivative of Phenylephrine) is reported as an ingredient of Metaoxedrin SAD in the following countries:

• Denmark

International Drug Name Search

Ameproxen

Ameproxen may be available in the countries listed below.

Ingredient matches for Ameproxen

Naproxen

Naproxen sodium salt (a derivative of Naproxen) is reported as an ingredient of Ameproxen in the following countries:

• Vietnam

International Drug Name Search

Puricap

Puricap may be available in the countries listed below.

Ingredient matches for Puricap

Anastrozole

Anastrozole is reported as an ingredient of Puricap in the following countries:

• Argentina

International Drug Name Search

Liberanit

Liberanit may be available in the countries listed below.

Ingredient matches for Liberanit

Acetic Acid

Acetic Acid 4% (a derivative of Acetic Acid) is reported as an ingredient of Liberanit in the following countries:

• Germany

International Drug Name Search

Litalir

Litalir may be available in the countries listed below.

Ingredient matches for Litalir

Hydroxycarbamide

Hydroxycarbamide is reported as an ingredient of Litalir in the following countries:

• Austria


• Bosnia & Herzegowina


• Croatia (Hrvatska)


• Czech Republic


• Germany


• Hungary


• Philippines


• Serbia


• Slovakia


• Slovenia


• Switzerland

International Drug Name Search

Mediprost

Mediprost may be available in the countries listed below.

Ingredient matches for Mediprost

Alprostadil

Alprostadil alfadex (a derivative of Alprostadil) is reported as an ingredient of Mediprost in the following countries:

• Japan

International Drug Name Search

Penegra

Penegra may be available in the countries listed below.

Ingredient matches for Penegra

Sildenafil

Sildenafil citrate (a derivative of Sildenafil) is reported as an ingredient of Penegra in the following countries:

• Ethiopia


• India


• Myanmar

International Drug Name Search

Pharmatex

Pharmatex may be available in the countries listed below.

Ingredient matches for Pharmatex

Benzalkonium Chloride

Benzalkonium chloride (a derivative of Benzalkonium) is reported as an ingredient of Pharmatex in the following countries:

• Algeria


• Argentina


• Estonia


• France


• Georgia


• Hungary


• Israel


• Latvia


• Lithuania


• Luxembourg


• Portugal


• Romania


• Russian Federation


• Serbia


• Slovakia


• Tunisia

International Drug Name Search

Amlodipino Davur

Amlodipino Davur may be available in the countries listed below.

Ingredient matches for Amlodipino Davur

Amlodipine

Amlodipine mesilate (a derivative of Amlodipine) is reported as an ingredient of Amlodipino Davur in the following countries:

• Spain

International Drug Name Search

Mirtazapina Ur

Mirtazapina Ur may be available in the countries listed below.

Ingredient matches for Mirtazapina Ur

Mirtazapine

Mirtazapine is reported as an ingredient of Mirtazapina Ur in the following countries:

• Spain

International Drug Name Search

Tramadol Genfar

Tramadol Genfar may be available in the countries listed below.

Ingredient matches for Tramadol Genfar

Tramadol

Tramadol is reported as an ingredient of Tramadol Genfar in the following countries:

• Colombia

Tramadol hydrochloride (a derivative of Tramadol) is reported as an ingredient of Tramadol Genfar in the following countries:

• Peru

International Drug Name Search

Captopril Stada

Captopril Stada may be available in the countries listed below.

Ingredient matches for Captopril Stada

Captopril

Captopril is reported as an ingredient of Captopril Stada in the following countries:

• Denmark


• Germany


• Spain


• Vietnam

International Drug Name Search

Cardicol

Cardicol may be available in the countries listed below.

Ingredient matches for Cardicol

Amlodipine

Amlodipine besilate (a derivative of Amlodipine) is reported as an ingredient of Cardicol in the following countries:

• Dominican Republic

International Drug Name Search

Trinacol

Trinacol may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Trinacol

Sulfadiazine

Sulfadiazine is reported as an ingredient of Trinacol in the following countries:

• Ireland


• United Kingdom

Trimethoprim

Trimethoprim is reported as an ingredient of Trinacol in the following countries:

• Ireland


• United Kingdom

International Drug Name Search

Argi-U

Argi-U may be available in the countries listed below.

Ingredient matches for Argi-U

Arginine

Arginine hydrochloride (a derivative of Arginine) is reported as an ingredient of Argi-U in the following countries:

• Japan

International Drug Name Search

Blutal

Blutal may be available in the countries listed below.

Ingredient matches for Blutal

Chondroitin Polysulfate

Chondroitin Polysulfate iron complex (a derivative of Chondroitin Polysulfate) is reported as an ingredient of Blutal in the following countries:

• Japan

International Drug Name Search

Mitaprogen

Mitaprogen may be available in the countries listed below.

Ingredient matches for Mitaprogen

Flopropione

Flopropione is reported as an ingredient of Mitaprogen in the following countries:

• Japan

International Drug Name Search

AteHexal

AteHexal may be available in the countries listed below.

Ingredient matches for AteHexal

Atenolol

Atenolol is reported as an ingredient of AteHexal in the following countries:

• Australia


• Austria


• Bulgaria


• Czech Republic


• Germany


• Luxembourg

International Drug Name Search

Pegabtanib Octasodium

Pegabtanib Octasodium may be available in the countries listed below.

Ingredient matches for Pegabtanib Octasodium

Pegaptanib

Pegabtanib Octasodium (USAN) is known as Pegaptanib in the US.

International Drug Name Search

Glossary

USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Marbofloxacin

In some countries, this medicine may only be approved for veterinary use.

Scheme

Rec.INN

CAS registry number (Chemical Abstracts Service)

0115550-35-1

Chemical Formula

C17-H19-F-N4-O4

Molecular Weight

362

Therapeutic Category

Antibacterial: Gyrase inhibitor

Chemical Names

9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[3,2,1-ij][4,1,2,]benzoxadiazine-6-carboxylic acid

9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol[3,2,1-ij]benzoxadiazine-6-carboxylic acid (WHO)

Foreign Names

• Marbofloxacinum (Latin)
• Marbofloxacin (German)
• Marbofloxacine (French)
• Marbofloxacino (Spanish)

Generic Names

• Marbofloxacin (OS: BAN)
• Ro 9-1168 (IS)
• Marbofloxacin for Veterinary Use (PH: Ph. Eur. 6)
• Marbofloxacinum ad usum veterinarium (PH: Ph. Eur. 6)

Brand Names

• Aurizon (Marbofloxacin and Clotrimazole, + Dexamethasone (veterinary use))
  Vetochas, Germany; Vetoquinol, Luxembourg; Vetoquinol Biowet, Poland; Via Vet, Sweden



• Marbocyl Bolus (veterinary use)
  Vetoquinol, Belgium



• Marbocyl S (veterinary use)
  Vetoquinol, Austria; Vetoquinol, Belgium; Vetoquinol, Netherlands



• Marbocyl (veterinary use)
  Ati, Italy; Laboratoire Vétoquinol, France; Selecta, Germany; Vetochas, Germany; Vetoquinol, Austria; Vetoquinol, Belgium; Vetoquinol, Switzerland; Vetoquinol, United Kingdom; Vetoquinol, Ireland; Vetoquinol, Luxembourg; Vetoquinol, Netherlands; Vétoquinol, Portugal; Via Vet, Sweden



• Zeniquin (veterinary use)
  Pfizer Animal Health, Australia; Pfizer Animal Health, United States; Pfizer Animal Health, South Africa

International Drug Name Search

Glossary

BAN	British Approved Name
IS	Inofficial Synonym
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
WHO	World Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

Tiogam

Tiogam may be available in the countries listed below.

Ingredient matches for Tiogam

Tiaprofenic Acid

Tiaprofenic Acid is reported as an ingredient of Tiogam in the following countries:

• Japan

International Drug Name Search

Chemmart Cephalexin

Chemmart Cephalexin may be available in the countries listed below.

Ingredient matches for Chemmart Cephalexin

Cefalexin

Cefalexin monohydrate (a derivative of Cefalexin) is reported as an ingredient of Chemmart Cephalexin in the following countries:

• Australia

International Drug Name Search

Ermac

Ermac may be available in the countries listed below.

Ingredient matches for Ermac

Erythromycin

Erythromycin is reported as an ingredient of Ermac in the following countries:

• Bangladesh

International Drug Name Search

Min-a-pon

Min-a-pon may be available in the countries listed below.

Ingredient matches for Min-a-pon

Nimesulide

Nimesulide is reported as an ingredient of Min-a-pon in the following countries:

• Greece

International Drug Name Search

Rozalin

Rozalin may be available in the countries listed below.

Ingredient matches for Rozalin

Dorzolamide

Dorzolamide is reported as an ingredient of Rozalin in the following countries:

• Poland

International Drug Name Search

Calvepen

Calvepen may be available in the countries listed below.

Ingredient matches for Calvepen

Phenoxymethylpenicillin

Phenoxymethylpenicillin calcium (a derivative of Phenoxymethylpenicillin) is reported as an ingredient of Calvepen in the following countries:

• Ireland

International Drug Name Search

Cetirizine hydrochloride and Pseudoephedrine hydrochloride

Ingredient matches for Cetirizine hydrochloride and Pseudoephedrine hydrochloride

Cetirizine

Cetirizine dihydrochloride (a derivative of Cetirizine) is reported as an ingredient of Cetirizine hydrochloride and Pseudoephedrine hydrochloride in the following countries:

• United States

Pseudoephedrine

Pseudoephedrine hydrochloride (a derivative of Pseudoephedrine) is reported as an ingredient of Cetirizine hydrochloride and Pseudoephedrine hydrochloride in the following countries:

• United States

International Drug Name Search

Lastet S

Lastet S may be available in the countries listed below.

Ingredient matches for Lastet S

Etoposide

Etoposide is reported as an ingredient of Lastet S in the following countries:

• Japan

International Drug Name Search

Triocaps

Triocaps may be available in the countries listed below.

Ingredient matches for Triocaps

Chlorphenamine

Chlorphenamine maleate (a derivative of Chlorphenamine) is reported as an ingredient of Triocaps in the following countries:

• Switzerland

Phenylephrine

Phenylephrine hydrochloride (a derivative of Phenylephrine) is reported as an ingredient of Triocaps in the following countries:

• Switzerland

International Drug Name Search

Tofiel

Tofiel may be available in the countries listed below.

Ingredient matches for Tofiel

Tofisopam

Tofisopam is reported as an ingredient of Tofiel in the following countries:

• Japan

International Drug Name Search

Parkines

Parkines may be available in the countries listed below.

Ingredient matches for Parkines

Trihexyphenidyl

Trihexyphenidyl hydrochloride (a derivative of Trihexyphenidyl) is reported as an ingredient of Parkines in the following countries:

• Japan

International Drug Name Search

Percof

Percof may be available in the countries listed below.

Ingredient matches for Percof

Levodropropizine

Levodropropizine is reported as an ingredient of Percof in the following countries:

• Brazil

International Drug Name Search

Benclart

Benclart may be available in the countries listed below.

Ingredient matches for Benclart

Glibenclamide

Glibenclamide is reported as an ingredient of Benclart in the following countries:

• Japan

International Drug Name Search

Perindopril Hexal

Perindopril Hexal may be available in the countries listed below.

Ingredient matches for Perindopril Hexal

Perindopril

Perindopril is reported as an ingredient of Perindopril Hexal in the following countries:

• Luxembourg

International Drug Name Search

Tantum Lemon

Tantum Lemon may be available in the countries listed below.

Ingredient matches for Tantum Lemon

Benzydamine

Benzydamine hydrochloride (a derivative of Benzydamine) is reported as an ingredient of Tantum Lemon in the following countries:

• Austria


• Bulgaria


• Lithuania


• Poland


• Romania


• Serbia

International Drug Name Search

Lubrilax

Lubrilax may be available in the countries listed below.

Ingredient matches for Lubrilax

Sodium Picosulfate

Sodium Picosulfate is reported as an ingredient of Lubrilax in the following countries:

• Spain

International Drug Name Search

Mutamycin

In the US, Mutamycin (mitomycin systemic) is a member of the drug class antibiotics/antineoplastics and is used to treat Bladder Cancer, Pancreatic Cancer and Stomach Cancer.

US matches:

• Mutamycin

Ingredient matches for Mutamycin

Mitomycin

Mitomycin is reported as an ingredient of Mutamycin in the following countries:

• Romania


• United States

International Drug Name Search

Goforan

Goforan may be available in the countries listed below.

Ingredient matches for Goforan

Cefotaxime

Cefotaxime sodium salt (a derivative of Cefotaxime) is reported as an ingredient of Goforan in the following countries:

• Indonesia

International Drug Name Search

Risperanne

Risperanne may be available in the countries listed below.

Ingredient matches for Risperanne

Risperidone

Risperidone is reported as an ingredient of Risperanne in the following countries:

• Denmark

International Drug Name Search

Comet

Comet may be available in the countries listed below.

Ingredient matches for Comet

Metformin

Metformin hydrochloride (a derivative of Metformin) is reported as an ingredient of Comet in the following countries:

• Bangladesh

International Drug Name Search

Locoid C

Locoid C may be available in the countries listed below.

Ingredient matches for Locoid C

Chlorquinaldol

Chlorquinaldol is reported as an ingredient of Locoid C in the following countries:

• New Zealand

Hydrocortisone

Hydrocortisone 17α-butyrate (a derivative of Hydrocortisone) is reported as an ingredient of Locoid C in the following countries:

• New Zealand

International Drug Name Search

Rasagiline mesylate

Rasagiline mesylate may be available in the countries listed below.

Ingredient matches for Rasagiline mesylate

Rasagiline

Rasagiline mesylate (USAN) is known as Rasagiline in the US.

International Drug Name Search

Glossary

USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Minims Mydriatics and Cylcoplegics

Minims Mydriatics and Cylcoplegics may be available in the countries listed below.

Ingredient matches for Minims Mydriatics and Cylcoplegics

Cyclopentolate

Cyclopentolate hydrochloride (a derivative of Cyclopentolate) is reported as an ingredient of Minims Mydriatics and Cylcoplegics in the following countries:

• Australia

International Drug Name Search

Half Securon

Half Securon may be available in the countries listed below.

UK matches:

• Half Securon SR (SPC)

Ingredient matches for Half Securon

Verapamil

Verapamil hydrochloride (a derivative of Verapamil) is reported as an ingredient of Half Securon in the following countries:

• United Kingdom

International Drug Name Search

Glossary

SPC	Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

Metronidazole Biosedra

Metronidazole Biosedra may be available in the countries listed below.

Ingredient matches for Metronidazole Biosedra

Metronidazole

Metronidazole is reported as an ingredient of Metronidazole Biosedra in the following countries:

• Tunisia

International Drug Name Search

Claricide

Claricide may be available in the countries listed below.

Ingredient matches for Claricide

Clarithromycin

Clarithromycin is reported as an ingredient of Claricide in the following countries:

• Ethiopia


• Turkey

International Drug Name Search

Lecetrin

Lecetrin may be available in the countries listed below.

Ingredient matches for Lecetrin

Levocetirizine

Levocetirizine dihydrochloride (a derivative of Levocetirizine) is reported as an ingredient of Lecetrin in the following countries:

• Bangladesh

International Drug Name Search

Ectren

Ectren may be available in the countries listed below.

Ingredient matches for Ectren

Quinapril

Quinapril hydrochloride (a derivative of Quinapril) is reported as an ingredient of Ectren in the following countries:

• Spain

International Drug Name Search

GenRX Paroxetine

GenRX Paroxetine may be available in the countries listed below.

Ingredient matches for GenRX Paroxetine

Paroxetine

Paroxetine hydrochloride (a derivative of Paroxetine) is reported as an ingredient of GenRX Paroxetine in the following countries:

• Australia

International Drug Name Search

Atorva

Atorva may be available in the countries listed below.

Ingredient matches for Atorva

Atorvastatin

Atorvastatin calcium (a derivative of Atorvastatin) is reported as an ingredient of Atorva in the following countries:

• India


• Myanmar


• Sri Lanka

International Drug Name Search

Farmasal

Farmasal may be available in the countries listed below.

Ingredient matches for Farmasal

Aspirin

Acetylsalicylic Acid is reported as an ingredient of Farmasal in the following countries:

• Indonesia

International Drug Name Search

Cazmar

Cazmar may be available in the countries listed below.

Ingredient matches for Cazmar

Retinol

Retinol is reported as an ingredient of Cazmar in the following countries:

• Argentina

International Drug Name Search

Ardeyhepan

Ardeyhepan may be available in the countries listed below.

Ingredient matches for Ardeyhepan

Silibinin

Silibinin is reported as an ingredient of Ardeyhepan in the following countries:

• Germany

International Drug Name Search

Bilol comp

Bilol comp. may be available in the countries listed below.

Ingredient matches for Bilol comp.

Bisoprolol

Bisoprolol fumarate (a derivative of Bisoprolol) is reported as an ingredient of Bilol comp. in the following countries:

• Switzerland

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Bilol comp. in the following countries:

• Switzerland

International Drug Name Search

Metoprolol-ratiopharm comp

Metoprolol-ratiopharm comp. may be available in the countries listed below.

Ingredient matches for Metoprolol-ratiopharm comp.

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Metoprolol-ratiopharm comp. in the following countries:

• Germany

Metoprolol

Metoprolol tartrate (a derivative of Metoprolol) is reported as an ingredient of Metoprolol-ratiopharm comp. in the following countries:

• Germany

International Drug Name Search

Balminil DM + Expectorant

Balminil DM + Expectorant may be available in the countries listed below.

Ingredient matches for Balminil DM + Expectorant

Dextromethorphan

Dextromethorphan hydrobromide (a derivative of Dextromethorphan) is reported as an ingredient of Balminil DM + Expectorant in the following countries:

• Canada

Guaifenesin

Guaifenesin is reported as an ingredient of Balminil DM + Expectorant in the following countries:

• Canada

International Drug Name Search

Poshinlen

Poshinlen may be available in the countries listed below.

Ingredient matches for Poshinlen

Dipyridamole

Dipyridamole is reported as an ingredient of Poshinlen in the following countries:

• Taiwan

International Drug Name Search

Framex

Framex may be available in the countries listed below.

Ingredient matches for Framex

Fluoxetine

Fluoxetine is reported as an ingredient of Framex in the following countries:

• Georgia

International Drug Name Search

Purinase

Purinase may be available in the countries listed below.

Ingredient matches for Purinase

Allopurinol

Allopurinol is reported as an ingredient of Purinase in the following countries:

• Philippines

International Drug Name Search

Citarabina Pfizer

Citarabina Pfizer may be available in the countries listed below.

Ingredient matches for Citarabina Pfizer

Cytarabine

Cytarabine is reported as an ingredient of Citarabina Pfizer in the following countries:

• Spain

International Drug Name Search

Atrederm

Atrederm may be available in the countries listed below.

Ingredient matches for Atrederm

Tocopherol, α-

Tocopherol, α- acetate (a derivative of Tocopherol, α-) is reported as an ingredient of Atrederm in the following countries:

• Poland

Tretinoin

Tretinoin is reported as an ingredient of Atrederm in the following countries:

• Poland

International Drug Name Search

Heart Gold

Heart Gold may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Heart Gold

Ivermectin

Ivermectin is reported as an ingredient of Heart Gold in the following countries:

• Australia

International Drug Name Search

Livarole

Livarole may be available in the countries listed below.

Ingredient matches for Livarole

Ketoconazole

Ketoconazole is reported as an ingredient of Livarole in the following countries:

• Russian Federation

International Drug Name Search

Benzethonium Chloride

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

D08AJ08

CAS registry number (Chemical Abstracts Service)

0000121-54-0

Chemical Formula

C27-H42-Cl-N-O2

Molecular Weight

448

Therapeutic Categories

Antiseptic

Disinfectant

Chemical Name

Benzenemethanaminium, N,N-dimethyl-N-[2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethyl]-, chloride

Foreign Names

• Benzethonii Chloridum (Latin)
• Benzethonium chlorid (German)
• Chlorure de Benzéthonium (French)
• Cloruro de bencetonio (Spanish)

Generic Names

• Benzethonium Chloride (OS: BAN)
• Benzetonio cloruro (OS: DCIT)
• Benzethoni chloridum (PH: Ph. Int. 2)
• Benzethonii chloridum (PH: Ph. Eur. 6)
• Benzéthonium (chlorure de) (PH: Ph. Eur. 6)
• Benzethonium Chloride (PH: BP 2010, JP XV, USP 32, Ph. Eur. 6)
• Benzethoniumchlorid (PH: Ph. Eur. 6)

Brand Names

• Antiseptol
  CCPC, Taiwan



• Bezeton
  Kenei Sakai SeiyakuTakeshi Sakai Seiyaku, Japan



• Cemaquin-Teva (Benzethonium Chloride and Ascorbic Acid)
  Teva Pharma, Switzerland



• Enzetonin
  Yoshida Seiyaku, Japan



• Hyamine
  Daiichi Sankyo, Japan



• Neo Golaseptine (Benzethonium Chloride and Chlorhexidine)
  SMB, Belgium



• Neostelin
  Green Nippon Shika YakuhinDental Pharm, Japan

International Drug Name Search

Glossary

BAN	British Approved Name
DCIT	Denominazione Comune Italiana
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)

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Mucolica

Mucolica may be available in the countries listed below.

Ingredient matches for Mucolica

Ambroxol

Ambroxol hydrochloride (a derivative of Ambroxol) is reported as an ingredient of Mucolica in the following countries:

• Indonesia

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Coronair

Coronair may be available in the countries listed below.

Ingredient matches for Coronair

Dipyridamole

Dipyridamole is reported as an ingredient of Coronair in the following countries:

• Belgium


• Luxembourg

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Retrovir AZT

Retrovir AZT may be available in the countries listed below.

Ingredient matches for Retrovir AZT

Zidovudine

Zidovudine is reported as an ingredient of Retrovir AZT in the following countries:

• Switzerland

International Drug Name Search

Methylin

In the US, Methylin (methylphenidate systemic) is a member of the drug class CNS stimulants and is used to treat ADHD and Narcolepsy.

US matches:

• Methylin


• Methylin Chewable Tablets


• Methylin ER Controlled-Release Tablets


• Methylin Solution


• Methylin ER


• Methylin Oral Solution

Ingredient matches for Methylin

Methylphenidate

Methylphenidate is reported as an ingredient of Methylin in the following countries:

• Argentina


• United States

Methylphenidate hydrochloride (a derivative of Methylphenidate) is reported as an ingredient of Methylin in the following countries:

• Argentina


• United States

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Esypan

Esypan may be available in the countries listed below.

Ingredient matches for Esypan

Clonazepam

Clonazepam is reported as an ingredient of Esypan in the following countries:

• Bangladesh

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Uniphyllin Continus tablets

1. Name Of The Medicinal Product

UNIPHYLLIN^® CONTINUS^® 200, 300 and 400 mg prolonged release tablets

2. Qualitative And Quantitative Composition

Tablets containing 200, 300 or 400 mg of Theophylline.

For excipients, see 6.1

3. Pharmaceutical Form

Prolonged release tablets

200 mg	Capsule shaped, white tablet, plain one side and 'U200' on the other.
300 mg	Capsule shaped, white tablet, plain one side and 'U300' on the other.
400 mg	Capsule shaped, white tablet with 'UNIPHYLLIN' on one side and the 'Napp logo' and 'U400' on the reverse.

4. Clinical Particulars

4.1 Therapeutic Indications

For the treatment and prophylaxis of bronchospasm associated with asthma, chronic obstructive pulmonary disease and chronic bronchitis. Also indicated for the treatment of left ventricular and congestive cardiac failure.

4.2 Posology And Method Of Administration

Route of Administration

Oral

The tablets should be swallowed whole and not crushed or chewed. Crushing or chewing the tablets may lead to a rapid release of theophylline with the potential for toxicity. Patients vary in their response to xanthines and it may be necessary to titrate the dose on an individual basis.

The usual maintenance dose for adults and elderly patients is 200 mg 12 hourly. This may be titrated to either 300 mg or 400 mg dependent on the therapeutic response. Plasma theophylline concentrations should ideally be maintained between 5 and 15 mg/l. A plasma level of 5 mg/l probably represents the lower level of clinical effectiveness. Significant adverse reactions are usually seen at plasma theophylline levels greater than 20 mg/l. Patients may require monitoring of plasma theophylline levels when higher dosages are prescribed or when co-administered with medication that reduces theophylline clearance.

Children: The maintenance dose is 9 mg/kg twice daily. Some children with chronic asthma require and tolerate much higher doses (10-16 mg/kg twice daily). Lower dosages (based on usual adult dose) may be required for adolescents.

It may be appropriate to administer a larger evening or morning dose in some patients, in order to achieve optimum therapeutic effect when symptoms are most severe e.g. at the time of the 'morning dip' in lung function.

In patients whose night time or day time symptoms persist despite other therapy and who are not currently receiving theophylline, then the total daily requirement of UNIPHYLLIN CONTINUS tablets (as specified above) may be added to their treatment regimen as either a single evening or morning dose.

4.3 Contraindications

Porphyria; hypersensitivity to xanthines or any of the tablet constituents; concomitant administration with ephedrine in children.

4.4 Special Warnings And Precautions For Use

The patient's response to therapy should be carefully monitored – worsening of asthma symptoms requires medical attention.

Use with caution in patients with cardiac disease, peptic ulcer, hyperthyroidism, severe hypertension, hepatic dysfunction, chronic alcoholism or acute febrile illness.

Caution should be exercised in elderly males with pre-existing partial outflow obstruction, such as prostatic enlargement, due to risk of urinary retention.

The half-life of theophylline may be prolonged in the elderly and in patients with heart failure, hepatic impairment or viral infections. Toxic accumulation may occur (see Section 4.9 Overdose). A reduction of dosage may be necessary in the elderly patient.

The hypokalaemia resulting from beta agonist therapy, steroids, diuretics and hypoxia may be potentiated by xanthines. Particular care is advised in patients suffering from severe asthma who require hospitalisation. It is recommended that serum potassium levels are monitored in such situations.

Severe side effects (hypertonia, convulsions, supraventricular tachycardia) may indicate serum concentrations of theophylline above therapeutic levels. Serum concentrations should be checked urgently and a decrease in the dose of theophylline may be required.

Alternative treatment is advised for patients with a history of seizure activity.

It is not possible to ensure bioequivalence between different prolonged release theophylline products. Therefore patients, once titrated to an effective dose, should not be changed from one prolonged release theophylline preparation to a different prolonged release preparation without re-titration and clinical assessment.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

The following increase clearance and it may therefore be necessary to increase dosage to ensure a therapeutic effect: aminoglutethimide, carbamazepine, isoprenaline, moracizine, phenytoin, rifampicin, ritonavir, sulphinpyrazone, barbiturates and hypericum perforatum. Plasma concentrations of theophylline can be reduced by concomitant use of the herbal remedy St John's Wort (hypericum perforatum). Smoking and alcohol consumption can also increase clearance of theophylline.

The following reduce clearance and a reduced dosage may therefore be necessary to avoid side-effects: allopurinol, carbimazole, cimetidine, ciprofloxacin, clarithromycin, diltiazem, disulfiram, erythromycin, fluconazole, interferon, isoniazid, methotrexate, mexiletine, nizatidine, norfloxacin, oxpentifylline, propafenone, propranolol, ofloxacin, thiabendazole, verapamil, viloxazine hydrochloride and oral contraceptives (see Section 4.9 Overdose). The concomitant use of theophylline and fluvoxamine should usually be avoided. Where this is not possible, patients should have their theophylline dose halved and plasma theophylline should be monitored closely.

Factors such as viral infections, liver disease and heart failure also reduce theophylline clearance (see Section 4.9 Overdose). There are conflicting reports concerning the potentiation of theophylline by influenza vaccine and physicians should be aware that interaction may occur. A reduction in dosage may be necessary in elderly patients. Thyroid disease or associated treatment may alter theophylline plasma levels. There is also a pharmacological interaction with adenosine, benzodiazepines, halothane, lomustine and lithium and these drugs should be used with caution.

Theophylline may decrease steady state phenytoin levels.

Xanthines can potentiate hypokalaemia resulting from beta₂ agonist therapy, steroids, diuretics and hypoxia. Particular caution is advised in severe asthma. It is recommended that serum potassium levels are monitored in such situations.

Co-administration with β-blockers may cause antagonism of bronchodilation; with ketamine may cause reduced convulsive threshold; with doxapram may cause increased CNS stimulation.

4.6 Pregnancy And Lactation

There are no adequate data from well controlled studies of the use of theophylline in pregnant women. Theophylline has been reported to give rise to teratogenic effects in mice, rats and rabbits (See section 5.3). The potential risk for humans is unknown. Theophylline should not be administered during pregnancy unless clearly necessary. Theophylline is secreted in breast milk, and may be associated with irritability in the infant, therefore it should only be given to breast feeding women when the anticipated benefits outweigh the risk to the child.

4.7 Effects On Ability To Drive And Use Machines

No known effects.

4.8 Undesirable Effects

The following adverse drug reactions have been reported in the post-marketing setting for theophylline. Frequencies of “not known” have been assigned as accurate frequencies cannot be estimated from the available clinical trial data.

Immune system disorders	Anaphylactic reaction
	Anaphylactoid reaction
	Hypersensitivity
Metabolism and nutrition disorders	Hyperuricaemia
Psychiatric disorders	Agitation
	Anxiety
	Insomnia
Nervous system disorders	Convulsions
	Dizziness
	Headache
	Tremor
Cardiac disorders	Atrial tachycardia
	Palpitations
	Sinus tachycardia
Gastrointestinal disorders	Abdominal pain
	Diarrhoea
	Gastric irritation
	Gastro-oesophageal reflux
	Nausea
	Vomiting
Skin and subcutaneous tissue disorders	Pruritus
	Rash
Renal and urinary disorders	Diuresis
	Urinary retention*

* Please refer to section 4.4 as theophylline may induce urinary retention in elderly males with pre-existing partial outflow obstruction.

4.9 Overdose

Over 3 g could be serious in an adult (40 mg/kg in a child). The fatal dose may be as little as 4.5 g in an adult (60 mg/kg in a child), but is generally higher.

Symptoms

Warning: Serious features may develop as long as 12 hours after overdosage with prolonged release formulations.

Alimentary features: Nausea, vomiting (which is often severe), epigastric pain and haematemesis. Consider pancreatitis if abdominal pain persists.

Neurological features: Restlessness, hypertonia, exaggerated limb reflexes and convulsions. Coma may develop in very severe cases.

Cardiovascular features: Sinus tachycardia is common. Ectopic beats and supraventricular and ventricular tachycardia may follow.

Metabolic features: Hypokalaemia due to shift of potassium from plasma into cells is common, can develop rapidly and may be severe. Hyperglycaemia, hypomagnesaemia and metabolic acidosis may also occur. Rhabdomyolysis may also occur.

Management

Activated charcoal or gastric lavage should be considered if a significant overdose has been ingested within 1-2 hours. Repeated doses of activated charcoal given by mouth can enhance theophylline elimination. Measure the plasma potassium concentration urgently, repeat frequently and correct hypokalaemia. BEWARE! If large amounts of potassium have been given, serious hyperkalaemia may develop during recovery. If plasma potassium is low, then the plasma magnesium concentration should be measured as soon as possible.

In the treatment of ventricular arrhythmias, proconvulsant antiarrhythmic agents such as lignocaine (lidocaine) should be avoided because of the risk of causing or exacerbating seizures.

Measure the plasma theophylline concentration regularly when severe poisoning is suspected, until concentrations are falling. Vomiting should be treated with an antiemetic such as metoclopramide or ondansetron.

Tachycardia with an adequate cardiac output is best left untreated. Beta-blockers may be given in extreme cases but not if the patient is asthmatic. Control isolated convulsions with intravenous diazepam. Exclude hypokalaemia as a cause.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Theophylline is a bronchodilator. In addition it affects the function of a number of cells involved in the inflammatory processes associated with asthma and chronic obstructive airways disease. Of most importance may be enhanced suppressor, T-lymphocyte activity and reduction of eosinophil and neutrophil function. These actions may contribute to an anti-inflammatory prophylactic activity in asthma and chronic obstructive airways disease. Theophylline stimulates the myocardium and produces a diminution of venous pressure in congestive heart failure leading to marked increase in cardiac output.

5.2 Pharmacokinetic Properties

Theophylline is well absorbed from UNIPHYLLIN CONTINUS tablets and at least 60% may be bound to plasma proteins. The main urinary metabolites are 1,3-dimethyl uric acid and 3-methylxanthine. About 10% is excreted unchanged.

5.3 Preclinical Safety Data

In studies in which mice, rats and rabbits were dosed during the period of organogenesis, theophylline produced teratogenic effects.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Hydroxyethylcellulose

Povidone (K25)

Cetostearyl Alcohol

Macrogol 6000

Talc

Magnesium Stearate

6.2 Incompatibilities

Not applicable.

6.3 Shelf Life

Three years.

6.4 Special Precautions For Storage

Do not store above 25°C.

6.5 Nature And Contents Of Container

Blister packs consisting of aluminium foil sealed to 250 μm PVC with a PVdC coating of at least 40 gsm thickness, containing 56 tablets.

6.6 Special Precautions For Disposal And Other Handling

None.

7. Marketing Authorisation Holder

Napp Pharmaceuticals Ltd

Cambridge Science Park

Milton Road

Cambridge CB4 0GW

8. Marketing Authorisation Number(S)

PL 16950/0066-0068

9. Date Of First Authorisation/Renewal Of The Authorisation

200 mg - 23 August 1979/15 May 2003

300 mg – 22 February 1988/15 May 2003

400 mg – 29 October 1982/15 May 2003

10. Date Of Revision Of The Text

22 March 2011

11 LEGAL CATEGORY

P

® UNIPHYLLIN, CONTINUS, NAPP and the Napp Device (logo) are Registered Trade Marks.

© 2010 – 2011 Napp Pharmaceuticals Ltd .

Paroxetin Sandoz

Paroxetin Sandoz may be available in the countries listed below.

Ingredient matches for Paroxetin Sandoz

Paroxetine

Paroxetine hydrochloride (a derivative of Paroxetine) is reported as an ingredient of Paroxetin Sandoz in the following countries:

• Denmark


• Estonia


• Germany


• Lithuania


• Netherlands


• Sweden

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Cregar

Cregar may be available in the countries listed below.

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Captopril

Captopril is reported as an ingredient of Cregar in the following countries:

• Greece

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Priom-D

Priom-D may be available in the countries listed below.

Ingredient matches for Priom-D

Domperidone

Domperidone is reported as an ingredient of Priom-D in the following countries:

• India

Omeprazole

Omeprazole is reported as an ingredient of Priom-D in the following countries:

• India

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Poly Tears

Poly Tears may be available in the countries listed below.

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Dextran

Dextran is reported as an ingredient of Poly Tears in the following countries:

• New Zealand

Hypromellose

Hypromellose is reported as an ingredient of Poly Tears in the following countries:

• New Zealand

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Berodual

Berodual may be available in the countries listed below.

Ingredient matches for Berodual

Fenoterol

Fenoterol is reported as an ingredient of Berodual in the following countries:

• Slovakia

Fenoterol hydrobromide (a derivative of Fenoterol) is reported as an ingredient of Berodual in the following countries:

• Austria


• Colombia


• Germany


• Hungary


• Indonesia


• Netherlands


• Poland


• Singapore


• Slovenia


• Switzerland


• Vietnam

Ipratropium

Ipratropium Bromide is reported as an ingredient of Berodual in the following countries:

• Austria


• Colombia


• Denmark


• Germany


• Hungary


• Indonesia


• Netherlands


• Poland


• Singapore


• Slovakia


• Slovenia


• Switzerland


• Vietnam

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Prednisone Sandoz

Prednisone Sandoz may be available in the countries listed below.

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Prednisone

Prednisone is reported as an ingredient of Prednisone Sandoz in the following countries:

• France

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Lamotrigine 1a Pharma

Lamotrigine 1a Pharma may be available in the countries listed below.

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Lamotrigine

Lamotrigine is reported as an ingredient of Lamotrigine 1a Pharma in the following countries:

• Hungary

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Cyclocaps Budesonid

Cyclocaps Budesonid may be available in the countries listed below.

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Budesonide

Budesonide is reported as an ingredient of Cyclocaps Budesonid in the following countries:

• Germany

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Mylepsinum

Mylepsinum may be available in the countries listed below.

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Primidone

Primidone is reported as an ingredient of Mylepsinum in the following countries:

• Germany

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Iromia

Iromia may be available in the countries listed below.

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Sodium Ferrous Citrate

Sodium Ferrous Citrate is reported as an ingredient of Iromia in the following countries:

• Japan

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Activase

In the US, Activase (alteplase systemic) is a member of the drug class thrombolytics and is used to treat Heart Attack, Ischemic Stroke and Pulmonary Embolism.

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• Activase

Ingredient matches for Activase

Alteplase

Alteplase is reported as an ingredient of Activase in the following countries:

• Canada


• United States

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Josamine

Josamine may be available in the countries listed below.

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Glucosamine

Glucosamine sulfate (a derivative of Glucosamine) is reported as an ingredient of Josamine in the following countries:

• Taiwan

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Bezafibrat ratiopharm

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Bezafibrate

Bezafibrate is reported as an ingredient of Bezafibrat-ratiopharm in the following countries:

• Austria


• Germany

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Ceftazidim Mylan

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Ceftazidime

Ceftazidime pentahydrate (a derivative of Ceftazidime) is reported as an ingredient of Ceftazidim Mylan in the following countries:

• Netherlands

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Cefarinol

Cefarinol may be available in the countries listed below.

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Cefalexin

Cefalexin monohydrate (a derivative of Cefalexin) is reported as an ingredient of Cefarinol in the following countries:

• Argentina

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Betahistine Walmark

Betahistine Walmark may be available in the countries listed below.

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Betahistine

Betahistine dihydrochloride (a derivative of Betahistine) is reported as an ingredient of Betahistine Walmark in the following countries:

• Poland


• Slovakia

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Betabion

Betabion may be available in the countries listed below.

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Betaxolol

Betaxolol hydrochloride (a derivative of Betaxolol) is reported as an ingredient of Betabion in the following countries:

• Poland

Thiamine

Thiamine hydrochloride (a derivative of Thiamine) is reported as an ingredient of Betabion in the following countries:

• Germany


• Sweden

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Apo-Clozapine

Apo-Clozapine may be available in the countries listed below.

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Clozapine

Clozapine is reported as an ingredient of Apo-Clozapine in the following countries:

• Canada

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Taenia-Passin

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Niclosamide

Niclosamide is reported as an ingredient of Taenia-Passin in the following countries:

• Ethiopia

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